报告题目:

金属纳米材料在癌症治疗中的应用

报告人:

张育淼

所在单位:

天津大学

报告人简介:

张育淼，天津大学合成生物与生物制造学院教授/博士生导师。主持或参与国家级人才项目、国自然面上项目、国家重点研发青年项目等。获优秀留学生奖(每年全球500人)、天津大学“我心目中的好导师”、“优秀论文指导教师”、Wiley威立中国高贡献作者和University at Buffalo优秀博士论文奖等荣誉。主要从事纳米生物医用材料的科学研究，以第一作者/通讯作者在Nat. Nanotech.，Nat. Commun.，Adv. Mater., JACS等期刊上发表科技论文60余篇。担任BME Mat等期刊青年编委、中国生物材料学会复合材料分会委员、中华医学会组织修复与再生分会青年学组委员、天津市整合医学会干细胞与转化医学专委会委员、天津市纳米医学专委会委员、纳米肿瘤学委员会委员、科技部外国专家项目评审人。

报告摘要:

The focus of this talk is primarily on the design of functional metal-based biomaterials and their biomedical applications. One example is manganese nanoparticles as a scaffold that are capable of coordinating with a wide variety of biomolecules such as STING agonists, siRNA, peptides (e.g. antigens) and proteins (e.g. Cas9) with the advantages of ease of preparation and responsive-release. Different approaches of anchoring metals on nanoparticles will be introduced including use of metal chelators or natural metalloproteins, and in situ reduction of metals on scaffolds. In addition, important biological roles of nutritious metals will be investigated and applied in immune regulation, synergistic activation of STING with STING agonists, and enhancement of gene editing of Cas9 as an enzymatic cofactor. We are particularly interested in harnessing endogenous nutritious metals. Going forward, rational design of multiple functional nanoparticles and their tremendous potentials as powerful therapeutic tools for metalloimmunotherapy and cuprotosis will be systematically discussed.